Tarnopolsky’s work on McArdle disease was funded through a donation from Giant Tiger stores, and work on mitochondrial disease was funded through a donation from Warren Lammert and Family.
Sport discus trial#
Tarnopolsky has enrolled patients in a clinical trial for Amicus Therapeutics. Tarnopolsky has received speaker honoraria and a grant (exercise in GAA knockout mice) from Genzyme. For the risk of rhabdomyolysis to remain low, exercise testing and prescription must be properly conducted based on professional standards.ĭr. Healthcare professionals should be able to recognize the basic signs of exertional rhabdomyolysis so prompt treatment can be administered. Creatine monohydrate does not appear to be a precipitating factor for exertional rhabdomyolysis. Although the prevalence of rhabdomyolysis is low, instances still occur where exercise is improperly prescribed or used as punishment, or incomplete medical history is taken, and exertional rhabdomyolysis occurs. Additionally, the references of papers identified through this search were examined for relevant studies. PubMed and SPORTDiscus databases were searched using the terms rhabdomyolysis, muscle damage, creatine, creatine supplementation, creatine monohydrate, and phosphocreatine. The objective of this article is to review the literature on exertional rhabdomyolysis, identify precipitating factors, and examine the role of the dietary supplement creatine monohydrate. The causes of rhabdomyolysis are numerous and can include direct muscle injury, unaccustomed exercise, ischemia, extreme temperatures, electrolyte abnormalities, endocrinologic conditions, genetic disorders, autoimmune disorders, infections, drugs, toxins, and venoms. Exertional (exercise-induced) rhabdomyolysis is a potentially life threatening condition that has been the subject of research, intense discussion, and media attention.
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